Renzo Mezzacapo was born in Italy in the small town in Tuscany Vivo d' Orcia in the province of Siena.
After the 2nd World War his family moved to Piombino, where his father was a worker at the Ilva Steelworks; he attended a technical school.
Although he spent only a few months in Monte Amiata, he has always felt deeply attached to his native town, to the province of Siena, and especially to the Val d'Orcia. In 1969 he was hired by Breda Siderurgica in Sesto San Giovanni and came into contact with the “1968 movement” in Milan, which he lived with intensity.
Although he was enrolled at Univerisity to read political science, he neither frequented university life nor took any exam, preferring to attend an evening art course organised by Sesto San Giovanni Council.
It was not a happy experience nor was it of educational value. It was during this period that he discovered, in an extremely culturally active Milan, the Churches and the Museums that served as essential elements in his artistic experience.
In 1971 he returned to live in Piombino with his wife, having been transferred to Italsider for work.

His children were born: Marco and Irene.
In 1988 he completely broke with the industrial sector in which he had been working, and he resigned in favour of a full-time artistic career.
In 1984 he mounted the most significant exhibitions, and became recognised at a national level.
He works in complex cycles which are filled with tension and existential quests.
The cycle entitled “If this is a man” dates from the beginning of the 80's, and is a very personal research into his and other's fears.
Half-way through the 80's, there followed the cycle on symphonic music and particularly some symphonic “tales”. Mezzacapo's Tuscan and Siennese origins find important points of reference here, by using pure gold on the one hand, and on the other a return to the polypytch.
The cycle “The Beach of Memory” follows, started in 1989 with the work that gives its name to a particularly articulated work.
The cycle dedicated to “Everyday Journeys” follows. It is a series of works in which the mystery of storytelling becomes the element of an almost metaphysical language.
In the last years he creates the cycle inspired by “Ovidio's Metamorphosis” and the cycle dedicated to “Mediterranean Sea”; in this cycles the artist try to conjugate the mystery of sea depths, meant as mental space, with history and legends of the “Myth”, a still alive element in the mystery of our daily life.
In this moment he is working for the cycle “The Revealed Riddle” inspired by “the mystery of things”, as he says, that is the main subject of his paintings, realised with a symbolic-fantastic style and a particularly accurate technique that has its sources in the history of Tuscan painting.